Casemiro is back from suspension for the Red Devils, who are without Donny van de Beek and Axel Tuanzebe to long-term injuries. Both Diogo Dalot and Anthony Martial will also miss out.
Jadon Sancho is back in training at Carrington following an absence due to a fitness concern and Erik ten Hag continues to be patient with the player ahead of an eventual matchday selection.
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Ten Hag told reporters: “All the players who were not available for the Arsenal game, so Dalot, Martial, Sancho, are also not available for tomorrow.”
David De Gea is picked in goal with Tom Heaton benched while Lisandro Martinez keeps his place. Harry Maguire is not in the squad.
Marcus Rashford joins a first-choice frontline of the available players.
Manchester United XI: De Gea; Wan-Bissaka, Lindelof, Martinez, Malacia; Eriksen, Casemiro; Antony, Fernandes, Rashford; Weghorst.
Subs: Heaton, Varane, Williams, Fred, Mainoo, McTominay, Pellistri, Elanga, Garnacho.